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Indications And Usage Neomycin And Polymyxin B Sulfates Solution For Irrigation Is Indicated For Short-Term Use (Up To 10 Days) As A Continuous Irrigant Or Rinse In The Urinary Bladder Of Abacteriuric Patients To Help Prevent Bacteriuria And Gram-Negative Rod Septicemia Associated With The Use Of Indwelling Catheters. Since Organisms Gain Entrance To The Bladder By Way Of, Through, And Around The Catheter, Significant Bacteriuria Is Induced By Bacterial Multiplication In The Bladder Urine, In The Mucoid Film Often Present Between Catheter And Urethra, And In Other Sites. Urinary Tract Infection May Result From The Repeated Presence In The Urine Of Large Numbers Of Pathogenic Bacteria. The Use Of Closed Systems With Indwelling Catheters Has Been Shown To Reduce The Risk Of Infection. A Three-Way Closed Catheter System With Constant Neomycin-Polymyxin B Bladder Rinse Is Indicated To Prevent The Development Of Infection While Using Indwelling Catheters. If Uropathogens Are Isolated, They Should Be Identified And Tested For Susceptibility So That Appropriate Antimicrobial Therapy For Systemic Use Can Be Initiated.
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