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1 Indications And Usage Amitiza Is A Chloride Channel Activator Indicated For The Treatment Of: Chronic Idiopathic Constipation (Cic) In Adults. ( 1.1 ) Opioid-Induced Constipation (Oic) In Adult Patients With Chronic, Non-Cancer Pain, Including Patients With Chronic Pain Related To Prior Cancer Or Its Treatment Who Do Not Require Frequent (E.g., Weekly) Opioid Dosage Escalation. ( 1.2 ) Limitations Of Use: Effectiveness Of Amitiza In The Treatment Of Oic In Patients Taking Diphenylheptane Opioids (E.g., Methadone) Has Not Been Established. ( 1.2 , 7.1 ) Irritable Bowel Syndrome With Constipation (Ibs-C) In Women ≥ 18 Years Old. ( 1.3 ) 1.1 Chronic Idiopathic Constipation In Adults Amitiza ® Is Indicated For The Treatment Of Chronic Idiopathic Constipation (Cic) In Adults. 1.2 Opioid-Induced Constipation In Adult Patients With Chronic Non-Cancer Pain Amitiza Is Indicated For The Treatment Of Opioid-Induced Constipation (Oic) In Adult Patients With Chronic Non-Cancer Pain, Including Patients With Chronic Pain Related To Prior Cancer Or Its Treatment Who Do Not Require Frequent (E.g., Weekly) Opioid Dosage Escalation. Limitations Of Use: Effectiveness Of Amitiza In The Treatment Of Opioid-Induced Constipation In Patients Taking Diphenylheptane Opioids (E.g., Methadone) Has Not Been Established. [See Clinical Studies (14.2) ] 1.3 Irritable Bowel Syndrome With Constipation Amitiza Is Indicated For The Treatment Of Irritable Bowel Syndrome With Constipation (Ibs-C) In Women At Least 18 Years Old.
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