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1 Indications And Usage Iloperidone Tablets Are Indicated For The Treatment Of Schizophrenia In Adults. When Deciding Among The Alternative Treatments Available For This Condition, The Prescriber Should Consider The Finding That Iloperidone Tablets Are Associated With Prolongation Of The Qtc Interval [See Warnings And Precautions (5.3) ] . Prolongation Of The Qtc Interval Is Associated In Some Other Drugs With The Ability To Cause Torsade De Pointes-Type Arrhythmia, A Potentially Fatal Polymorphic Ventricular Tachycardia Which Can Result In Sudden Death. In Many Cases This Would Lead To The Conclusion That Other Drugs Should Be Tried First. Whether Iloperidone Tablets Will Cause Torsade De Pointes Or Increase The Rate Of Sudden Death Is Not Yet Known. Patients Must Be Titrated To An Effective Dose Of Iloperidone Tablets. Thus, Control Of Symptoms May Be Delayed During The First 1 To 2 Weeks Of Treatment Compared To Some Other Antipsychotic Drugs That Do Not Require A Similar Titration. Prescribers Should Be Mindful Of This Delay When Selecting An Antipsychotic Drug For The Treatment Of Schizophrenia [See Dosage And Administration (2.1) And Clinical Studies (14) ] . Iloperidone Is An Atypical Antipsychotic Indicated For The Treatment Of Schizophrenia In Adults. ( 1 , 14 ) In Choosing Among Treatments, Prescribers Should Consider The Ability Of Iloperidone To Prolong The Qt Interval And The Use Of Other Drugs First. Prescribers Should Also Consider The Need To Titrate Iloperidone Slowly To Avoid Orthostatic Hypotension, Which May Lead To Delayed Effectiveness Compared To Some Other Drugs That Do Not Require Similar Titration. ( 2 , 5 , 14 )
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