|
Indications And Usage Trientine Hydrochloride Is Indicated In The Treatment Of Patients With Wilson's Disease Who Are Intolerant Of Penicillamine. Clinical Experience With Trientine Hydrochloride Is Limited And Alternate Dosing Regimens Have Not Been Well-Characterized; All Endpoints In Determining An Individual Patient's Dose Have Not Been Well Defined. Trientine Hydrochloride And Penicillamine Cannot Be Considered Interchangeable. Trientine Hydrochloride Should Be Used When Continued Treatment With Penicillamine Is No Longer Possible Because Of Intolerable Or Life Endangering Side Effects. Unlike Penicillamine, Trientine Hydrochloride Is Not Recommended In Cystinuria Or Rheumatoid Arthritis. The Absence Of A Sulfhydryl Moiety Renders It Incapable Of Binding Cystine And, Therefore, It Is Of No Use In Cystinuria. In 15 Patients With Rheumatoid Arthritis, Trientine Hydrochloride Was Reported Not To Be Effective In Improving Any Clinical Or Biochemical Parameter After 12 Weeks Of Treatment. Trientine Hydrochloride Is Not Indicated For Treatment Of Biliary Cirrhosis.
|