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1 Indications And Usage Bosentan Tablets Are Indicated For The Treatment Of Pulmonary Arterial Hypertension (Pah) (Who Group 1): In Adults To Improve Exercise Ability And To Decrease Clinical Worsening. Studies Establishing Effectiveness Included Predominantly Patients With Who Functional Class Ii-Iv Symptoms And Etiologies Of Idiopathic Or Heritable Pah (60%), Pah Associated With Connective Tissue Diseases (21%), And Pah Associated With Congenital Heart Disease With Left-To-Right Shunts (18%) [See Clinical Studies ( 14.1 )] . Bosentan Tablets Are An Endothelin Receptor Antagonist Indicated For The Treatment Of Pulmonary Arterial Hypertension (Pah) (Who Group 1): In Adults To Improve Exercise Ability And To Decrease Clinical Worsening. Studies Establishing Effectiveness Included Predominantly Patients With Who Functional Class Ii-Iv Symptoms And Etiologies Of Idiopathic Or Heritable Pah (60%), Pah Associated With Connective Tissue Diseases (21%), And Pah Associated With Congenital Heart Disease With Left-To-Right Shunts (18%) ( 1 ).
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