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Indications And Usage Midodrine Hydrochloride Tablets, Usp Are Indicated For The Treatment Of Symptomatic Orthostatic Hypotension (Oh). Because Midodrine Hydrochloride Tablets, Usp Can Cause Marked Elevation Of Supine Blood Pressure (Bp>200 Mmhg Systolic), It Should Be Used In Patients Whose Lives Are Considerably Impaired Despite Standard Clinical Care, Including Non-Pharmacologic Treatment (Such As Support Stockings), Fluid Expansion, And Lifestyle Alterations. The Indication Is Based On Midodrine Hydrochloride Tablets, Usp Effect On Increases In 1-Minute Standing Systolic Blood Pressure, A Surrogate Marker Considered Likely To Correspond To A Clinical Benefit. At Present, However, Clinical Benefits Of Midodrine Hydrochloride Tablets, Usp Principally Improved Ability To Perform Life Activities, Have Not Been Established. Further Clinical Trials Are Underway To Verify And Describe The Clinical Benefits Of Midodrine Hydrochloride Tablets, Usp. After Initiation Of Treatment, Midodrine Hydrochloride Tablets, Usp Should Be Continued Only For Patients Who Report Significant Symptomatic Improvement.
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