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Indications And Usage Mirtazapine Tablets, Usp Are Indicated For The Treatment Of Major Depressive Disorder. The Efficacy Of Mirtazapine In The Treatment Of Major Depressive Disorder Was Established In 6 - Week Controlled Trials Of Outpatients Whose Diagnoses Corresponded Most Closely To The Diagnostic And Statistical Manual Of Mental Disorders -3 Rd Edition (Dsm-Iii) Category Of Major Depressive Disorder (See Clinical Pharmacology ). A Major Depressive Episode (Dsm-Iv) Implies A Prominent And Relatively Persistent (Nearly Every Day For At Least 2 Weeks) Depressed Or Dysphoric Mood That Usually Interferes With Daily Functioning, And Includes At Least 5 Of The Following 9 Symptoms: Depressed Mood, Loss Of Interest In Usual Activities, Significant Change In Weight And/or Appetite, Insomnia Or Hypersomnia, Psychomotor Agitation Or Retardation, Increased Fatigue, Feelings Of Guilt Or Worthlessness, Slowed Thinking Or Impaired Concentration, A Suicide Attempt, Or Suicidal Ideation. The Effectiveness Of Mirtazapine In Hospitalized Depressed Patients Has Not Been Adequately Studied. The Efficacy Of Mirtazapine, Usp In Maintaining A Response In Patients With Major Depressive Disorder For Up To 40 Weeks Following 8 To 12 Weeks Of Initial Open-Label Treatment Was Demonstrated In A Placebo-Controlled Trial. Nevertheless, The Physician Who Elects To Use Mirtazapine, Usp For Extended Periods Should Periodically Re-Evaluate The Long-Term Usefulness Of The Drug For The Individual Patient (See Clinical Pharmacology ).
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