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1 Indications And Usage Tramadol Hydrochloride Extended-Release Tablets Are Indicated For The Management Of Pain Severe Enough To Require Daily, Around-The-Clock, Long-Term Opioid Treatment And For Which Alternative Treatment Options Are Inadequate. Limitations Of Use Because Of The Risks Of Addiction, Abuse, And Misuse With Opioids, Even At Recommended Doses, And Because Of The Greater Risks Of Overdose And Death With Extended-Release Opioid Formulations [See Warnings And Precautions ( 5.1 )] , Reserve Tramadol Hydrochloride Extended-Release Tablets For Use In Patients For Whom Alternative Treatment Options (E.g., Non-Opioid Analgesics Or Immediate-Release Opioids) Are Ineffective, Not Tolerated, Or Would Be Otherwise Inadequate To Provide Sufficient Management Of Pain. Tramadol Hydrochloride Extended-Release Tablets Are Not Indicated As An As-Needed (Prn) Analgesic. Tramadol Hydrochloride Extended-Release Tablets Are An Opioid Agonist Indicated For The Management Of Pain Severe Enough To Require Daily Around-The-Clock, Long-Term Opioid Treatment And For Which Alternative Treatment Options Are Inadequate. ( 1 ) Limitations Of Use Because Of The Risks Of Addiction, Abuse, And Misuse With Opioids, Even At Recommended Doses, And Because Of The Greater Risks Of Overdose And Death With Extended-Release Opioid Formulations, Reserve Tramadol Hydrochloride Extended-Release Tablets For Use In Patients For Whom Alternative Treatment Options (E.g., Non-Opioid Analgesics Or Immediate-Release Opioids) Are Ineffective, Not Tolerated, Or Would Be Otherwise Inadequate To Provide Sufficient Management Of Pain. ( 1 ) Tramadol Hydrochloride Extended-Release Tablets Are Not Indicated As An As-Needed (Prn) Analgesic. ( 1 )
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