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1 Indications And Usage Demerol Injection Is Indicated For Preoperative Medication, Support Of Anesthesia, And Obstetrical Analgesia. Demerol Injection Is Indicated For The Management Of Pain Severe Enough To Require An Opioid Analgesic And For Which Alternative Treatments Are Inadequate. Demerol Injection Is Indicated For Preoperative Medication, Support Of Anesthesia, For Obstetrical Analgesia, And For The Management Of Pain Severe Enough To Require An Opioid Analgesic And For Which Alternative Treatments Are Inadequate. Limitations Of Use Because Of The Risks Of Addiction, Abuse, And Misuse With Opioids, Even At Recommended Doses, Reserve Demerol Injection For Use In Patients For Whom Alternative Treatment Options [E.g., Non-Opioid Analgesics Or Opioid Combination Products]: Have Not Been Tolerated, Or Are Not Expected To Be Tolerated, Have Not Provided Adequate Analgesia, Or Are Not Expected To Provide Adequate Analgesia Limitations Of Use Because Of The Risks Of Addiction, Abuse, And Misuse With Opioids, Even At Recommended Doses [See Warnings And Precautions (5.1) ] , Reserve Demerol Injection For Use In Patients For Whom Alternative Treatment Options [E.g., Non-Opioid Analgesics Or Opioid Combination Products]: Have Not Been Tolerated, Or Are Not Expected To Be Tolerated Have Not Provided Adequate Analgesia, Or Are Not Expected To Provide Adequate Analgesia Demerol Injection Should Not Be Used For Treatment Of Chronic Pain. Prolonged Demerol Injection Use May Increase The Risk Of Toxicity (E.g. Seizures) From The Accumulation Of The Meperidine Metabolite, Normeperidine.
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