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1 Indications And Usage Actoplus Met Is Indicated As An Adjunct To Diet And Exercise To Improve Glycemic Control In Adults With Type 2 Diabetes Mellitus When Treatment With Both Pioglitazone And Metformin Is Appropriate [See Clinical Studies (14) ] . Important Limitations Of Use Pioglitazone Exerts Its Antihyperglycemic Effect Only In The Presence Of Endogenous Insulin. Actoplus Met Should Not Be Used To Treat Type 1 Diabetes Or Diabetic Ketoacidosis, As It Would Not Be Effective In These Settings. Use Caution In Patients With Liver Disease [See Warnings And Precautions (5.5) ] . Actoplus Met Is A Thiazolidinedione And Biguanide Combination Product Indicated As An Adjunct To Diet And Exercise To Improve Glycemic Control In Adults With Type 2 Diabetes Mellitus When Treatment With Both Pioglitazone And Metformin Is Appropriate. ( 1 , 14 ) Important Limitations Of Use: • Not For Treatment Of Type 1 Diabetes Or Diabetic Ketoacidosis. ( 1 )
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