|
1 Indications And Usage Bosentan Is Indicated For The Treatment Of Pulmonary Arterial Hypertension (Pah) (Who Group 1): • In Adults To Improve Exercise Ability And To Decrease Clinical Worsening. Studies Establishing Effectiveness Included Predominantly Patients With Who Functional Class Ii-Iv Symptoms And Etiologies Of Idiopathic Or Heritable Pah (60%), Pah Associated With Connective Tissue Diseases (21%), And Pah Associated With Congenital Heart Disease With Left-To-Right Shunts (18%) [See Clinical Studies (14.1) ] . Bosentan Is An Endothelin Receptor Antagonist Indicated For The Treatment Of Pulmonary Arterial Hypertension (Pah) (Who Group 1): • In Adults To Improve Exercise Ability And To Decrease Clinical Worsening. Studies Establishing Effectiveness Included Predominantly Patients With Who Functional Class Ii-Iv Symptoms And Etiologies Of Idiopathic Or Heritable Pah (60%), Pah Associated With Connective Tissue Diseases (21%), And Pah Associated With Congenital Heart Disease With Left-To-Right Shunts (18%) ( 1 ).
|