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1. Indications And Usage Bosentan Is Indicated For The Treatment Of Pulmonary Arterial Hypertension (Pah) (Who Group 1) To Improve Exercise Ability And To Decrease Clinical Worsening. Studies Establishing Effectiveness Included Predominantly Patients With Who Functional Class Ii-Iv Symptoms And Etiologies Of Idiopathic Or Heritable Pah (60%), Pah Associated With Connective Tissue Diseases (21%), And Pah Associated With Congenital Heart Disease With Left-To-Right Shunts (18%) [See Clinical Studies (14.1) ] . Bosentan Is An Endothelin Receptor Antagonist Indicated For The Treatment Of Pulmonary Arterial Hypertension (Pah) (Who Group 1) To Improve Exercise Ability And To Decrease Clinical Worsening. Studies Establishing Effectiveness Included Predominantly Patients With Who Functional Class Ii-Iv Symptoms And Etiologies Of Idiopathic Or Heritable Pah (60%), Pah Associated With Connective Tissue Diseases (21%), And Pah Associated With Congenital Heart Disease With Left-To-Right Shunts (18%) ( 1 ).
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