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1 Indications And Usage Pyridostigmine Bromide Is Indicated For Pretreatment Against The Lethal Effects Of Soman Nerve Agent Poisoning. Pyridostigmine Bromide Is Intended For Use In Conjunction With Protective Garments, Including A Mask. At The First Sign Of Nerve Agent Poisoning, Pyridostigmine Bromide Should Be Stopped, And Atropine And Pralidoxime Therapy Started Immediately. The Evidence For The Effectiveness Of Pyridostigmine Bromide As Pretreatment Against Soman-Induced Toxicity Was Derived From Animal Studies Alone. [See Nonclinical Toxicology (13.2) .] For Military Medical Use Only Pyridostigmine Bromide Is A Reversible Cholinesterase Inhibitor Indicated For Pretreatment Against The Lethal Effects Of Soman Nerve Agent Poisoning. ( 1 ) Pyridostigmine Bromide Is For Use In Conjunction With Protective Garments, Including A Gas Mask, And Immediate Atropine And Pralidoxime Therapy At The First Sign Of Nerve Agent Poisoning. ( 1 )
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