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Indications And Usage Trientine Hydrochloride Capsules Are Indicated In The Treatment Of Patients With Wilson's Disease Who Are Intolerant Of Penicillamine. Clinical Experience With Trientine Hydrochloride Capsules Is Limited And Alternate Dosing Regimens Have Not Been Well-Characterized; All Endpoints In Determining An Individual Patient's Dose Have Not Been Well Defined. Trientine Hydrochloride Capsules And Penicillamine Cannot Be Considered Interchangeable. Trientine Hydrochloride Capsules Should Be Used When Continued Treatment With Penicillamine Is No Longer Possible Because Of Intolerable Or Life Endangering Side Effects. Unlike Penicillamine, Trientine Hydrochloride Capsules Are Not Recommended In Cystinuria Or Rheumatoid Arthritis. The Absence Of A Sulfhydryl Moiety Renders It Incapable Of Binding Cystine And, Therefore, It Is Of No Use In Cystinuria. In 15 Patients With Rheumatoid Arthritis, Trientine Hydrochloride Capsules Were Reported Not To Be Effective In Improving Any Clinical Or Biochemical Parameter After 12 Weeks Of Treatment. Trientine Hydrochloride Capsules Are Not Indicated For Treatment Of Biliary Cirrhosis.
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